ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0019.2-9 | Neonatal diabetes mellitus | ESPEYB19

2.9. SGLT2 inhibitors therapy protects glucotoxicity-induced [beta]-cell failure in a mouse model of human KATP-induced diabetes through mitigation of oxidative and ER stress

ZA Shyr , Z Yan , A Ustione , EM Egan , MS Remedi

PLoS One. 2022 Feb 18;17(2):e0258054. doi: 10.1371/journal.pone.0258054. PMID: 35180212.Brief Summary: This mouse model of diabetes describes how early administration of sodium glucose transporter 2 (SGLT2) inhibitors can protect pancreatic beta-cells from glucotoxicity damage. Early use of SGLT2 inhibitors can revert/prevent beta-cell failure in mice with diabetes due to KATP channel de...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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